Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities
نویسندگان
چکیده
منابع مشابه
Green Synthesis and Antimicrobial Activity of Some Eugenol Derivatives
Eugenol derivatives (3a-f) were synthesized under microwave irradiation in aq KOH by reacting different aromatic acid chlorides (2a-f) with Eugenol. The newly synthesized compounds were confirmed by spectral analysis and evaluated for antimicrobial activity. Some compounds showed promising activities.
متن کاملSynthesis and Antimycobacterial Activity of some Triazole Derivatives–New Route to Functionalized Triazolopyridazines
A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...
متن کاملSynthesis and Antimycobacterial Activity of some Triazole Derivatives–New Route to Functionalized Triazolopyridazines
A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...
متن کاملSynthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
Sodium 1-[4-amino-5-mercapto-4H-(1,2,4)triazol-3-yl]heptadecane-1-sulfonate 2 has been used as a new precursor to synthesize some important biologically active heterocycles. Reaction of 2 with carbon disulphide in pyridine and acid chlorides yields the 1,2,4-triazole derivatives 3, 4a and 4b. Condensation of 2 with appropriate aldehydes gives 5a-c which have been cyclized by treating with thiog...
متن کاملLeishmanicidal activity of passifloricin A and derivatives.
Several natural and hemisyntetic passifloricins were assayed against Leishmania panamensis amastigotes. High leishmanicidal activity as well as toxicity was observed. The structure of a new compound is also reported.
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2018
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2018.01.046